Yaz (Drospirenone + Ethinyl Estradiol)

Oral tablet (3mg/0.02mg), 24/4 regimenAvailable in all 50 states

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

hormones

Yaz (Drospirenone + Ethinyl Estradiol)Yaz (Drospirenone + Ethinyl Estradiol)

Combined oral contraceptive with drospirenone (spironolactone-derived progestin) offering antimineralocorticoid and antiandrogenic properties. FDA-approved for contraception, PMDD, and acne.

Dual contraception + PMDD management

Antiandrogenic properties reduce acne/hirsutism

Minimizes fluid retention vs other COCs

24/4 dosing reduces hormone-free interval symptoms

No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible

How it works

Mechanism of action

EE suppresses FSH to prevent follicular development; drospirenone suppresses LH to prevent ovulation. Antimineralocorticoid activity blocks aldosterone reducing fluid retention. Antiandrogenic activity reduces sebum and acne.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

Total TestosteroneLC/MS
Free TestosteroneEquilibrium Dialysis
Estradiol, Sensitive / UltrasensitiveLC/MS
Sex Hormone Binding Globulin (SHBG)
ProgesteroneLC/MSFemale panel
Prolactin
Luteinizing Hormone (LH)
Follicle-Stimulating Hormone (FSH)
hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

Cortisol
DHEA-S

Growth hormone / IGF-1

Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

Thyroid Stimulating Hormone (TSH)
Free T4
Free T3

Heart Health

9 markers

Cardiovascular health

Total Cholesterol
HDL Cholesterol
LDL Cholesterol
LDL:HDL Ratio
VLDL Cholesterol
Triglycerides
Apolipoprotein-B (ApoB)
C-Reactive Protein, High Sensitivity (hsCRP)
Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

Blood Glucose
Fasting Insulin
HbA1c

Organ Function

26 markers

Liver & pancreas

AST
ALT
Bilirubin, Total
γ-Glutamyl Transferase (GGT)

Kidney function

BUN
Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

Glucose
Blood Urea Nitrogen (BUN)
Creatinine
eGFR
BUN/Creatinine Ratio
Sodium
Potassium
Chloride
Carbon Dioxide, Total
Calcium
Protein, Total
Albumin
Globulin, Total
Albumin/Globulin (A/G) Ratio
Alkaline Phosphatase (ALP)
AST
ALT

Prostate health

Prostate-Specific Antigen (PSA)Male panel
Free PSAMale panel
% Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

Vitamin D, 25-OHD (25-Hydroxy)
Magnesium, RBC

Iron status

Iron
Iron Saturation
TIBC
UIBC
Ferritin

Complete Blood Count (CBC)

White Blood Count (WBC)
Red Blood Count (RBC)
Hemoglobin (Hgb)
Hematocrit (HCT)
MCV
MCH
MCHC
Red Cell Distribution Width (RDW)
Platelets
Neutrophils
Neutrophils (Absolute)
Lymphocytes
Lymphocytes (Absolute)
Neutrophil/Lymphocyte Ratio
Monocytes
Monocytes (Absolute)
Eosinophils
Eosinophils (Absolute)
Basophils
Basophils (Absolute)
Immature Cells
Immature Granulocytes
Immature Granulocytes (Absolute)
NRBC, w/ Reflex for Immature Cells

Clinical evidence

The research behind Yaz (Drospirenone + Ethinyl Estradiol).

Drospirenone/EE vs Placebo for PMDD: RCT

Obstetrics & Gynecology (2005)

Significantly reduced PMDD symptom scores across emotional and physical domains, leading to FDA approval.

Safety profile

Monitoring & safety information.

Commonly reported side effects

Nausea
Breast tenderness
Headache
Spotting
Mood changes
Decreased libido

Less common but serious risks

VTE (slightly higher than levonorgestrel COCs)
Arterial thrombosis (especially smokers >35)
Hyperkalemia (with ACEi, ARBs, K-sparing diuretics)

Generally not appropriate for

Smoking in women >35
History of VTE or arterial thromboembolism
Migraine with aura
Liver tumor/impairment
Conditions predisposing to hyperkalemia

Typical monitoring

Blood pressure
Serum potassium (if concurrent K-affecting meds)
Lipid panel annually

FAQ

Quick answers.

Combined oral contraceptive with drospirenone (spironolactone-derived progestin) offering antimineralocorticoid and antiandrogenic properties. FDA-approved for contraception, PMDD, and acne.

Dual contraception + PMDD management. Antiandrogenic properties reduce acne/hirsutism. Minimizes fluid retention vs other COCs. 24/4 dosing reduces hormone-free interval symptoms.

Common side effects include: nausea, breast tenderness, headache, spotting, mood changes, decreased libido. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.

View all FAQs

See all FAQs

Combined oral contraceptive with drospirenone (spironolactone-derived progestin) offering antimineralocorticoid and antiandrogenic properties. FDA-approved for contraception, PMDD, and acne.

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.