Vitamin D and K Supplementation for Bone and Cardiovascular Health
Nutrients (2017)
Combined D3+K2 improved bone mineral density and reduced arterial stiffness more than either alone.
How it works
Marek's Guided Optimization® Program combines advanced lab testing, a dedicated health coach and medical provider, and a personalized treatment plan, all built around your data.
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The process
1
Start your assessment
Complete your 45-min intake assessment
2
Get your labs drawn
4,000 partnered lab locations nationwide
3
Review with your coach
Screen-by-screen lab review
4
Receive your protocol
Treatment delivered to your door
Why Marek
The only program pairing you with a dedicated health coach and medical provider, built on precision diagnostics, with no subscription required.
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Meet our co-founder
Derek
Co-Founder · MPMD Podcast
"Over time, I found it incredibly difficult to get medical oversight for myself and my family that reflected the latest research, and that was preventative. That's why I started Marek Health."
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What we test
Every client's lab panel is hand-selected from 1,000+ available biomarkers, built around their specific goals.
Panel categories
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Treatments
700+ medical provider-prescribed therapies built from your labs. Browse by category or explore the full formulary.
Vitamin D3 + K2
Oral capsule (5000IU D3 + 180mcg K2 MK-7), Injectable Vitamin D3 (100,000 IU/mL)Available in all 50 statesMarketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.
longevity
Vitamin D3 + K2Vitamin D3 + K2
Synergistic combination of vitamin D3 and vitamin K2 (MK-7 form). D3 promotes calcium absorption; K2 directs calcium to bones and teeth while preventing arterial calcification. Critical combination for bone health and cardiovascular protection.
Corrects vitamin D deficiency
Synergistic bone protection
Prevents arterial calcification
Immune modulation
No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible
How it works
Mechanism of action
D3 converted to 25(OH)D then 1,25(OH)2D (calcitriol), activating VDR receptors for calcium/phosphorus absorption and immune modulation. K2 activates osteocalcin (directs Ca to bone) and matrix Gla protein (prevents vascular calcification).
The baseline panel.
Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →
Hormone Profile
12 markers
Sex hormones
- Total TestosteroneLC/MS
- Free TestosteroneEquilibrium Dialysis
- Estradiol, Sensitive / UltrasensitiveLC/MS
- Sex Hormone Binding Globulin (SHBG)
- ProgesteroneLC/MSFemale panel
- Prolactin
- Luteinizing Hormone (LH)
- Follicle-Stimulating Hormone (FSH)
- hCG, Total, QuantitativeFemale panel, pre-menopause
Adrenals & neurosteroids
- Cortisol
- DHEA-S
Growth hormone / IGF-1
- Insulin-Like Growth Factor I (IGF-1)
Thyroid Status
3 markers
Thyroid hormones
- Thyroid Stimulating Hormone (TSH)
- Free T4
- Free T3
Heart Health
9 markers
Cardiovascular health
- Total Cholesterol
- HDL Cholesterol
- LDL Cholesterol
- LDL:HDL Ratio
- VLDL Cholesterol
- Triglycerides
- Apolipoprotein-B (ApoB)
- C-Reactive Protein, High Sensitivity (hsCRP)
- Lipoprotein(a) (Lp(a))
Metabolism
3 markers
Insulin sensitivity
- Blood Glucose
- Fasting Insulin
- HbA1c
Organ Function
26 markers
Liver & pancreas
- AST
- ALT
- Bilirubin, Total
- γ-Glutamyl Transferase (GGT)
Kidney function
- BUN
- Creatinine w/ eGFR
Comprehensive Metabolic Panel (CMP)
- Glucose
- Blood Urea Nitrogen (BUN)
- Creatinine
- eGFR
- BUN/Creatinine Ratio
- Sodium
- Potassium
- Chloride
- Carbon Dioxide, Total
- Calcium
- Protein, Total
- Albumin
- Globulin, Total
- Albumin/Globulin (A/G) Ratio
- Alkaline Phosphatase (ALP)
- AST
- ALT
Prostate health
- Prostate-Specific Antigen (PSA)Male panel
- Free PSAMale panel
- % Free PSAMale panel
Nutrient Status
31 markers
Vitamins & minerals
- Vitamin D, 25-OHD (25-Hydroxy)
- Magnesium, RBC
Iron status
- Iron
- Iron Saturation
- TIBC
- UIBC
- Ferritin
Complete Blood Count (CBC)
- White Blood Count (WBC)
- Red Blood Count (RBC)
- Hemoglobin (Hgb)
- Hematocrit (HCT)
- MCV
- MCH
- MCHC
- Red Cell Distribution Width (RDW)
- Platelets
- Neutrophils
- Neutrophils (Absolute)
- Lymphocytes
- Lymphocytes (Absolute)
- Neutrophil/Lymphocyte Ratio
- Monocytes
- Monocytes (Absolute)
- Eosinophils
- Eosinophils (Absolute)
- Basophils
- Basophils (Absolute)
- Immature Cells
- Immature Granulocytes
- Immature Granulocytes (Absolute)
- NRBC, w/ Reflex for Immature Cells
Clinical evidence
The research behind Vitamin D3 + K2.
Safety profile
Monitoring & safety information.
Commonly reported side effects
- Generally very well tolerated
- Hypercalcemia (rare, at very high D3 doses)
- GI upset
Less common but serious risks
- Vitamin D toxicity with excessive dosing (>10,000 IU/day chronic)
- Hypercalcemia
Generally not appropriate for
- Hypercalcemia
- Granulomatous disease (sarcoidosis)
- Concurrent warfarin (K2 antagonizes warfarin)
Typical monitoring
- 25(OH)D level (target 40 to 60 ng/mL)
- Serum calcium
- PTH
- INR if on warfarin
FAQ
Quick answers.
Synergistic combination of vitamin D3 and vitamin K2 (MK-7 form). D3 promotes calcium absorption; K2 directs calcium to bones and teeth while preventing arterial calcification. Critical combination for bone health and cardiovascular protection.
Corrects vitamin D deficiency. Synergistic bone protection. Prevents arterial calcification. Immune modulation. Broadly beneficial at population level.
Common side effects include: generally very well tolerated, hypercalcemia (rare, at very high d3 doses), gi upset. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
Synergistic combination of vitamin D3 and vitamin K2 (MK-7 form). D3 promotes calcium absorption; K2 directs calcium to bones and teeth while preventing arterial calcification. Critical combination for bone health and cardiovascular protection.
Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.