Tri-Mix

Injectable vial (Papaverine 30mg/mL + Phentolamine 1mg/mL + PGE1 10mcg/mL)Not available in all states

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

sexual health

Tri-MixTri-Mix

Intracavernosal injection combining three vasodilatory agents for erectile dysfunction refractory to oral PDE5 inhibitors. Water-based formulation injected directly into the corpus cavernosum.

Highest efficacy of any ED therapy (>90% response rate)

Effective when oral agents fail

Dose-titratable

Rapid onset (5 to 15 minutes)

No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible

How it works

Mechanism of action

Papaverine inhibits PDE and relaxes smooth muscle; phentolamine blocks alpha-adrenergic vasoconstriction; PGE1 (alprostadil) activates adenylate cyclase increasing cAMP. Triple mechanism produces synergistic vasodilation in penile vasculature.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

Total TestosteroneLC/MS
Free TestosteroneEquilibrium Dialysis
Estradiol, Sensitive / UltrasensitiveLC/MS
Sex Hormone Binding Globulin (SHBG)
ProgesteroneLC/MSFemale panel
Prolactin
Luteinizing Hormone (LH)
Follicle-Stimulating Hormone (FSH)
hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

Cortisol
DHEA-S

Growth hormone / IGF-1

Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

Thyroid Stimulating Hormone (TSH)
Free T4
Free T3

Heart Health

9 markers

Cardiovascular health

Total Cholesterol
HDL Cholesterol
LDL Cholesterol
LDL:HDL Ratio
VLDL Cholesterol
Triglycerides
Apolipoprotein-B (ApoB)
C-Reactive Protein, High Sensitivity (hsCRP)
Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

Blood Glucose
Fasting Insulin
HbA1c

Organ Function

26 markers

Liver & pancreas

AST
ALT
Bilirubin, Total
γ-Glutamyl Transferase (GGT)

Kidney function

BUN
Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

Glucose
Blood Urea Nitrogen (BUN)
Creatinine
eGFR
BUN/Creatinine Ratio
Sodium
Potassium
Chloride
Carbon Dioxide, Total
Calcium
Protein, Total
Albumin
Globulin, Total
Albumin/Globulin (A/G) Ratio
Alkaline Phosphatase (ALP)
AST
ALT

Prostate health

Prostate-Specific Antigen (PSA)Male panel
Free PSAMale panel
% Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

Vitamin D, 25-OHD (25-Hydroxy)
Magnesium, RBC

Iron status

Iron
Iron Saturation
TIBC
UIBC
Ferritin

Complete Blood Count (CBC)

White Blood Count (WBC)
Red Blood Count (RBC)
Hemoglobin (Hgb)
Hematocrit (HCT)
MCV
MCH
MCHC
Red Cell Distribution Width (RDW)
Platelets
Neutrophils
Neutrophils (Absolute)
Lymphocytes
Lymphocytes (Absolute)
Neutrophil/Lymphocyte Ratio
Monocytes
Monocytes (Absolute)
Eosinophils
Eosinophils (Absolute)
Basophils
Basophils (Absolute)
Immature Cells
Immature Granulocytes
Immature Granulocytes (Absolute)
NRBC, w/ Reflex for Immature Cells

Clinical evidence

The research behind Tri-Mix.

Tri-Mix Intracavernosal Injection for ED

Journal of Urology (1996)

Triple-agent combination achieved >90% erection adequate for intercourse with lower individual drug doses reducing side effects vs monotherapy.

Safety profile

Monitoring & safety information.

Commonly reported side effects

Penile pain at injection site
Bruising
Penile fibrosis (with repeated use)
Dizziness

Less common but serious risks

Priapism (erection >4 hours, medical emergency)
Penile fibrosis/Peyronie's disease
Hypotension

Generally not appropriate for

Sickle cell disease
Concurrent anticoagulation (relative)
Penile anatomical deformity
History of priapism

Typical monitoring

Response assessment and dose titration
Penile exam for fibrosis
Blood pressure

FAQ

Quick answers.

Compounded intracavernosal injection combining three vasodilatory agents for erectile dysfunction refractory to oral PDE5 inhibitors. Water-based formulation injected directly into the corpus cavernosum.

Highest efficacy of any ED therapy (>90% response rate). Effective when oral agents fail. Dose-titratable. Rapid onset (5 to 15 minutes).

Common side effects include: penile pain at injection site, bruising, penile fibrosis (with repeated use), dizziness. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.

View all FAQs

See all FAQs

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.