TadalafilTadalafil

Long-acting PDE5 inhibitor with 17.5-hour half-life enabling daily dosing for continuous erectile function support. Beyond ED, demonstrates cardiovascular, endothelial, and pulmonary vascular benefits making it increasingly relevant in longevity medicine.

HSA/FSA eligible · No commitmentHSA/FSA eligible · No commitment

Sexual Health · PDE5

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

How it works

From sign-up to treatment.From sign-up to your first dose.

Take the assessment

45-min intake with your dedicated health coach. A free health-score quiz is available before the paid intake.

Get your labs drawn

Complete lab panel ordered by your provider, drawn at any of 4,000 partnered lab locations nationwide. Results typically return within 14 days.

Provider reviews your results

A licensed medical provider reviews your labs and history to evaluate whether Tadalafil is appropriate for you. Eligibility and any prescription are determined at the provider's discretion.

If eligible, treatment ships to your door

If your provider prescribes Tadalafil, it ships from a licensed pharmacy. Your coach supports you through follow-up labs and ongoing monitoring.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

Total TestosteroneLC/MS
Free TestosteroneEquilibrium Dialysis
Estradiol, Sensitive / UltrasensitiveLC/MS
Sex Hormone Binding Globulin (SHBG)
ProgesteroneLC/MSFemale panel
Prolactin
Luteinizing Hormone (LH)
Follicle-Stimulating Hormone (FSH)
hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

Cortisol
DHEA-S

Growth hormone / IGF-1

Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

Thyroid Stimulating Hormone (TSH)
Free T4
Free T3

Heart Health

9 markers

Cardiovascular health

Total Cholesterol
HDL Cholesterol
LDL Cholesterol
LDL:HDL Ratio
VLDL Cholesterol
Triglycerides
Apolipoprotein-B (ApoB)
C-Reactive Protein, High Sensitivity (hsCRP)
Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

Blood Glucose
Fasting Insulin
HbA1c

Organ Function

26 markers

Liver & pancreas

AST
ALT
Bilirubin, Total
γ-Glutamyl Transferase (GGT)

Kidney function

BUN
Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

Glucose
Blood Urea Nitrogen (BUN)
Creatinine
eGFR
BUN/Creatinine Ratio
Sodium
Potassium
Chloride
Carbon Dioxide, Total
Calcium
Protein, Total
Albumin
Globulin, Total
Albumin/Globulin (A/G) Ratio
Alkaline Phosphatase (ALP)
AST
ALT

Prostate health

Prostate-Specific Antigen (PSA)Male panel
Free PSAMale panel
% Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

Vitamin D, 25-OHD (25-Hydroxy)
Magnesium, RBC

Iron status

Iron
Iron Saturation
TIBC
UIBC
Ferritin

Complete Blood Count (CBC)

White Blood Count (WBC)
Red Blood Count (RBC)
Hemoglobin (Hgb)
Hematocrit (HCT)
MCV
MCH
MCHC
Red Cell Distribution Width (RDW)
Platelets
Neutrophils
Neutrophils (Absolute)
Lymphocytes
Lymphocytes (Absolute)
Neutrophil/Lymphocyte Ratio
Monocytes
Monocytes (Absolute)
Eosinophils
Eosinophils (Absolute)
Basophils
Basophils (Absolute)
Immature Cells
Immature Granulocytes
Immature Granulocytes (Absolute)
NRBC, w/ Reflex for Immature Cells

The science

How Tadalafil works.

Selectively inhibits PDE5, preventing cGMP degradation in vascular smooth muscle. Increased cGMP causes NO-mediated vasodilation in penile corpus cavernosum, pulmonary vasculature, and systemic endothelium. Daily dosing provides continuous endothelial NO support.

Erectile dysfunctionBPH/LUTSPulmonary arterial hypertension (Adcirca)Raynaud's phenomenonEndothelial function optimization

Eligibility, dosing, and outcomes vary. Any prescription is at the discretion of a partnered licensed medical provider based on your labs and medical history.

Clinical evidence

The research behind Tadalafil.

Daily Tadalafil for BPH: Phase III

Journal of Urology (2012)

5mg daily significantly improved IPSS and IIEF scores vs placebo in men with BPH and ED.

PDE5 Inhibitors and Cardiovascular Outcomes

BMJ (2021)

Meta-analysis found PDE5 inhibitor use associated with 39% reduction in all-cause mortality and 36% reduction in cardiovascular events in men with T2DM.

Safety profile

Monitoring & safety information.

Commonly reported side effects

Headache
Dyspepsia
Back pain
Myalgia
Nasal congestion
Flushing

Less common but serious risks

Hypotension with nitrates (contraindicated)
Priapism (rare)
NAION, non-arteritic anterior ischemic optic neuropathy (very rare)
Hearing loss (very rare)

Generally not appropriate for

Concurrent nitrate therapy (absolute)
Alpha-blockers (caution, hypotension)
Severe hepatic impairment
Recent stroke or MI

Typical monitoring

Blood pressure
Erectile function (IIEF scores)
Visual/hearing symptoms
Prostate symptom scores (IPSS)

FAQ

Quick answers.

Long half-life enables daily low-dose use. Improves erectile function and spontaneity. BPH symptom improvement. Endothelial and cardiovascular protective effects. Blood pressure reduction (~3 to 5 mmHg).

Common side effects include: headache, dyspepsia, back pain, myalgia, nasal congestion, flushing. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.

View all FAQs

See all FAQs

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.