Rapamycin (Sirolimus)

Oral enteric-coated tablet (2mg), Topical cream (0.01%, Eternal)Not available in all states

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

longevity

Rapamycin (Sirolimus)Rapamycin (Sirolimus)

mTORC1 inhibitor with the strongest evidence for lifespan extension across species. The NIA ITP demonstrated 9 to 14% median lifespan extension in mice. Intermittent/pulsed dosing protocol in longevity medicine aims for immunomodulation rather than immunosuppression.

Strongest lifespan extension data of any drug in mammals

Enhances autophagy and cellular quality control

Intermittent dosing may improve immune function

Topical: reduces skin aging markers

No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible

How it works

Mechanism of action

Rapamycin (sirolimus) binds FKBP12, forming a complex that inhibits mTORC1. This suppresses protein synthesis (via S6K and 4E-BP1), enhances autophagy, and reduces cellular senescence.

At low, intermittent doses, the effect is immunomodulation rather than immunosuppression, and animal models show extended median lifespan. mTORC2 is not significantly inhibited at pulsed longevity dosing.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

Total TestosteroneLC/MS
Free TestosteroneEquilibrium Dialysis
Estradiol, Sensitive / UltrasensitiveLC/MS
Sex Hormone Binding Globulin (SHBG)
ProgesteroneLC/MSFemale panel
Prolactin
Luteinizing Hormone (LH)
Follicle-Stimulating Hormone (FSH)
hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

Cortisol
DHEA-S

Growth hormone / IGF-1

Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

Thyroid Stimulating Hormone (TSH)
Free T4
Free T3

Heart Health

9 markers

Cardiovascular health

Total Cholesterol
HDL Cholesterol
LDL Cholesterol
LDL:HDL Ratio
VLDL Cholesterol
Triglycerides
Apolipoprotein-B (ApoB)
C-Reactive Protein, High Sensitivity (hsCRP)
Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

Blood Glucose
Fasting Insulin
HbA1c

Organ Function

26 markers

Liver & pancreas

AST
ALT
Bilirubin, Total
γ-Glutamyl Transferase (GGT)

Kidney function

BUN
Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

Glucose
Blood Urea Nitrogen (BUN)
Creatinine
eGFR
BUN/Creatinine Ratio
Sodium
Potassium
Chloride
Carbon Dioxide, Total
Calcium
Protein, Total
Albumin
Globulin, Total
Albumin/Globulin (A/G) Ratio
Alkaline Phosphatase (ALP)
AST
ALT

Prostate health

Prostate-Specific Antigen (PSA)Male panel
Free PSAMale panel
% Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

Vitamin D, 25-OHD (25-Hydroxy)
Magnesium, RBC

Iron status

Iron
Iron Saturation
TIBC
UIBC
Ferritin

Complete Blood Count (CBC)

White Blood Count (WBC)
Red Blood Count (RBC)
Hemoglobin (Hgb)
Hematocrit (HCT)
MCV
MCH
MCHC
Red Cell Distribution Width (RDW)
Platelets
Neutrophils
Neutrophils (Absolute)
Lymphocytes
Lymphocytes (Absolute)
Neutrophil/Lymphocyte Ratio
Monocytes
Monocytes (Absolute)
Eosinophils
Eosinophils (Absolute)
Basophils
Basophils (Absolute)
Immature Cells
Immature Granulocytes
Immature Granulocytes (Absolute)
NRBC, w/ Reflex for Immature Cells

Clinical evidence

The research behind Rapamycin (Sirolimus).

Rapamycin extends lifespan in genetically heterogeneous mice (NIA ITP)

Nature (2009)

Median lifespan was extended by approximately 9% in male and 14% in female mice when treatment started at 600 days of age, a landmark animal study in longevity research.

Read study →

mTOR inhibition improves immune function in the elderly

Science Translational Medicine (2014)

Low-dose mTOR inhibition was associated with improved influenza vaccine response in elderly adults, suggesting immune enhancement at intermittent dosing.

Read study →

Safety profile

Monitoring & safety information.

Commonly reported side effects

Mouth sores / aphthous ulcers
Mild GI upset
Delayed wound healing
Lipid elevations (typically transient)

Less common but serious risks

Immunosuppression
Hyperlipidemia
Impaired wound healing
Glucose intolerance

Generally not appropriate for

Active infection
Planned surgery within 2 weeks
Severe hepatic impairment
Pregnancy

Typical monitoring

CBC with differential
Lipid panel
Fasting glucose / HbA1c
Liver function
Renal function

FAQ

Quick answers.

Eligibility, dose, and duration are determined by a partnered licensed medical provider based on your complete labs and medical history. A prescription is not guaranteed, your provider may recommend Rapamycin, a different therapy, or a non-pharmacologic approach.

Rapamycin (sirolimus) is an mTORC1 inhibitor originally approved for organ-transplant rejection. In longevity medicine it is studied as an intermittent / pulsed protocol intended for immunomodulation rather than immunosuppression. Published animal-model data is the strongest evidence base; human longevity outcomes are still being studied.

Commonly reported side effects include mouth sores, mild GI upset, transient lipid elevations, and slower wound healing. Less common but serious risks include immunosuppression, hyperlipidemia, and glucose intolerance. Your provider reviews your history to evaluate whether Rapamycin is appropriate.

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See all FAQs

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.