Intranasal Oxytocin Increases Trust in Humans
Nature (2005)
Kosfeld et al. demonstrated intranasal oxytocin significantly increased trust-based decisions in economic trust game, landmark study establishing oxytocin as a trust-enhancing compound.
Oxytocin
Nasal spray (100IU/mL)Available in all 50 statesMarketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.
sexual health
OxytocinOxytocin
Naturally occurring 9-amino-acid neuropeptide hormone. Intranasal delivery used off-label for social bonding, anxiety reduction, and sexual function enhancement. Reduces amygdala reactivity and HPA stress axis activity.
Anxiolytic and prosocial effects
Reduces cortisol stress response
Promotes parasympathetic tone
Enhances emotional recognition
No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible
How it works
Mechanism of action
Binds oxytocin receptors in brain (amygdala, nucleus accumbens), uterus, and immune tissues. CNS effects include reduced anxiety via amygdala dampening, enhanced trust and prosocial behavior, and HPA stress axis attenuation.
The baseline panel.
Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →
Hormone Profile
12 markers
Sex hormones
- Total TestosteroneLC/MS
- Free TestosteroneEquilibrium Dialysis
- Estradiol, Sensitive / UltrasensitiveLC/MS
- Sex Hormone Binding Globulin (SHBG)
- ProgesteroneLC/MSFemale panel
- Prolactin
- Luteinizing Hormone (LH)
- Follicle-Stimulating Hormone (FSH)
- hCG, Total, QuantitativeFemale panel, pre-menopause
Adrenals & neurosteroids
- Cortisol
- DHEA-S
Growth hormone / IGF-1
- Insulin-Like Growth Factor I (IGF-1)
Thyroid Status
3 markers
Thyroid hormones
- Thyroid Stimulating Hormone (TSH)
- Free T4
- Free T3
Heart Health
9 markers
Cardiovascular health
- Total Cholesterol
- HDL Cholesterol
- LDL Cholesterol
- LDL:HDL Ratio
- VLDL Cholesterol
- Triglycerides
- Apolipoprotein-B (ApoB)
- C-Reactive Protein, High Sensitivity (hsCRP)
- Lipoprotein(a) (Lp(a))
Metabolism
3 markers
Insulin sensitivity
- Blood Glucose
- Fasting Insulin
- HbA1c
Organ Function
26 markers
Liver & pancreas
- AST
- ALT
- Bilirubin, Total
- γ-Glutamyl Transferase (GGT)
Kidney function
- BUN
- Creatinine w/ eGFR
Comprehensive Metabolic Panel (CMP)
- Glucose
- Blood Urea Nitrogen (BUN)
- Creatinine
- eGFR
- BUN/Creatinine Ratio
- Sodium
- Potassium
- Chloride
- Carbon Dioxide, Total
- Calcium
- Protein, Total
- Albumin
- Globulin, Total
- Albumin/Globulin (A/G) Ratio
- Alkaline Phosphatase (ALP)
- AST
- ALT
Prostate health
- Prostate-Specific Antigen (PSA)Male panel
- Free PSAMale panel
- % Free PSAMale panel
Nutrient Status
31 markers
Vitamins & minerals
- Vitamin D, 25-OHD (25-Hydroxy)
- Magnesium, RBC
Iron status
- Iron
- Iron Saturation
- TIBC
- UIBC
- Ferritin
Complete Blood Count (CBC)
- White Blood Count (WBC)
- Red Blood Count (RBC)
- Hemoglobin (Hgb)
- Hematocrit (HCT)
- MCV
- MCH
- MCHC
- Red Cell Distribution Width (RDW)
- Platelets
- Neutrophils
- Neutrophils (Absolute)
- Lymphocytes
- Lymphocytes (Absolute)
- Neutrophil/Lymphocyte Ratio
- Monocytes
- Monocytes (Absolute)
- Eosinophils
- Eosinophils (Absolute)
- Basophils
- Basophils (Absolute)
- Immature Cells
- Immature Granulocytes
- Immature Granulocytes (Absolute)
- NRBC, w/ Reflex for Immature Cells
Clinical evidence
The research behind Oxytocin.
Safety profile
Monitoring & safety information.
Commonly reported side effects
- Headache
- Nasal irritation
- Nausea
- Paradoxical anxiety in some individuals
Less common but serious risks
- Paradoxical social hostility (context-dependent)
- Hyponatremia (high-dose IV only, not intranasal)
Generally not appropriate for
- Hypersensitivity
- Active hyponatremia
- Psychiatric conditions with paranoia
Typical monitoring
- Psychological assessments
- Electrolytes (sodium) with regular use
- Mood and behavioral response
FAQ
Quick answers.
Naturally occurring 9-amino-acid neuropeptide hormone. Intranasal delivery used off-label for social bonding, anxiety reduction, and sexual function enhancement. Reduces amygdala reactivity and HPA stress axis activity.
Anxiolytic and prosocial effects. Reduces cortisol stress response. Promotes parasympathetic tone. Enhances emotional recognition.
Common side effects include: headache, nasal irritation, nausea, paradoxical anxiety in some individuals. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
Naturally occurring 9-amino-acid neuropeptide hormone. Intranasal delivery used off-label for social bonding, anxiety reduction, and sexual function enhancement. Reduces amygdala reactivity and HPA stress axis activity.
Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.