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Methylene Blue

Oral capsule (5mg, 10mg), Liposomal capsule (25mg)Not available in all states

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

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Methylene BlueMethylene Blue

Phenothiazine dye with unique mitochondrial electron carrier properties. At low doses, acts as an alternative electron carrier in the mitochondrial electron transport chain, bypassing complex I/III deficiencies and reducing ROS. Emerging nootropic and neuroprotective agent.

Enhances mitochondrial ATP production

Neuroprotective in multiple models

Anti-tau aggregation

Potent antioxidant at low doses

No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible

How it works

Mechanism of action

Cycles between oxidized (MB+) and reduced (leucomethylene blue) forms, acting as an alternative electron shuttle in mitochondria from NADH to cytochrome c, bypassing dysfunctional complex I/III. Enhances mitochondrial respiration and ATP production. Also inhibits tau aggregation and monoamine oxidase A.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

  • Total TestosteroneLC/MS
  • Free TestosteroneEquilibrium Dialysis
  • Estradiol, Sensitive / UltrasensitiveLC/MS
  • Sex Hormone Binding Globulin (SHBG)
  • ProgesteroneLC/MSFemale panel
  • Prolactin
  • Luteinizing Hormone (LH)
  • Follicle-Stimulating Hormone (FSH)
  • hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

  • Cortisol
  • DHEA-S

Growth hormone / IGF-1

  • Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

  • Thyroid Stimulating Hormone (TSH)
  • Free T4
  • Free T3

Heart Health

9 markers

Cardiovascular health

  • Total Cholesterol
  • HDL Cholesterol
  • LDL Cholesterol
  • LDL:HDL Ratio
  • VLDL Cholesterol
  • Triglycerides
  • Apolipoprotein-B (ApoB)
  • C-Reactive Protein, High Sensitivity (hsCRP)
  • Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

  • Blood Glucose
  • Fasting Insulin
  • HbA1c

Organ Function

26 markers

Liver & pancreas

  • AST
  • ALT
  • Bilirubin, Total
  • γ-Glutamyl Transferase (GGT)

Kidney function

  • BUN
  • Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

  • Glucose
  • Blood Urea Nitrogen (BUN)
  • Creatinine
  • eGFR
  • BUN/Creatinine Ratio
  • Sodium
  • Potassium
  • Chloride
  • Carbon Dioxide, Total
  • Calcium
  • Protein, Total
  • Albumin
  • Globulin, Total
  • Albumin/Globulin (A/G) Ratio
  • Alkaline Phosphatase (ALP)
  • AST
  • ALT

Prostate health

  • Prostate-Specific Antigen (PSA)Male panel
  • Free PSAMale panel
  • % Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

  • Vitamin D, 25-OHD (25-Hydroxy)
  • Magnesium, RBC

Iron status

  • Iron
  • Iron Saturation
  • TIBC
  • UIBC
  • Ferritin

Complete Blood Count (CBC)

  • White Blood Count (WBC)
  • Red Blood Count (RBC)
  • Hemoglobin (Hgb)
  • Hematocrit (HCT)
  • MCV
  • MCH
  • MCHC
  • Red Cell Distribution Width (RDW)
  • Platelets
  • Neutrophils
  • Neutrophils (Absolute)
  • Lymphocytes
  • Lymphocytes (Absolute)
  • Neutrophil/Lymphocyte Ratio
  • Monocytes
  • Monocytes (Absolute)
  • Eosinophils
  • Eosinophils (Absolute)
  • Basophils
  • Basophils (Absolute)
  • Immature Cells
  • Immature Granulocytes
  • Immature Granulocytes (Absolute)
  • NRBC, w/ Reflex for Immature Cells

Clinical evidence

The research behind Methylene Blue.

Methylene Blue Enhances Memory and Mitochondrial Function

Neurobiology of Aging (2015)

Low-dose MB enhanced memory retention and increased cytochrome oxidase activity in hippocampus, demonstrating dose-dependent cognitive enhancement via mitochondrial mechanism.

Safety profile

Monitoring & safety information.

Commonly reported side effects

  • Blue-green discoloration of urine (expected)
  • GI upset
  • Headache
  • Blue tongue/oral coloring

Less common but serious risks

  • Serotonin syndrome (with SSRIs, SNRIs, MAOIs, CONTRAINDICATED)
  • Hemolytic anemia in G6PD deficiency
  • Dose-dependent: pro-oxidant at high doses

Generally not appropriate for

  • Serotonergic medications (SSRIs, SNRIs, MAOIs), serotonin syndrome risk
  • G6PD deficiency
  • Renal impairment (accumulation)

Typical monitoring

  • Serotonergic medication review (critical)
  • G6PD screening
  • Renal function
  • Cognitive assessments

FAQ

Quick answers.

Phenothiazine dye with unique mitochondrial electron carrier properties. At low doses, acts as an alternative electron carrier in the mitochondrial electron transport chain, bypassing complex I/III deficiencies and reducing ROS. Emerging nootropic and neuroprotective agent.
Enhances mitochondrial ATP production. Neuroprotective in multiple models. Anti-tau aggregation. Potent antioxidant at low doses. Memory enhancement in animal studies.
Common side effects include: blue-green discoloration of urine (expected), gi upset, headache, blue tongue/oral coloring. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
View all FAQs
See all FAQs

Phenothiazine dye with unique mitochondrial electron carrier properties. At low doses, acts as an alternative electron carrier in the mitochondrial electron transport chain, bypassing complex I/III deficiencies and reducing ROS. Emerging nootropic and neuroprotective agent.

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.