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Kyzatrex® (Oral Testosterone)

Oral capsule (200mg)Available in all 50 states

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

hormones

Kyzatrex® (Oral Testosterone)Kyzatrex® (Oral Testosterone)

Kyzatrex is an FDA-approved oral testosterone undecanoate using a lipid-based delivery system requiring ingestion with food. Absorbed via intestinal lymphatics, bypassing hepatic first-pass metabolism and avoiding hepatotoxicity of 17-alpha-alkylated oral androgens.

Non-injectable route

Avoids hepatotoxicity via lymphatic absorption

FDA-approved with established safety data

Twice-daily dosing provides stable levels

No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible

How it works

Mechanism of action

Absorbed through intestinal lymphatic channels, releasing free testosterone systemically. Peripheral esterases cleave the undecanoate ester to yield free testosterone acting at androgen receptors.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

  • Total TestosteroneLC/MS
  • Free TestosteroneEquilibrium Dialysis
  • Estradiol, Sensitive / UltrasensitiveLC/MS
  • Sex Hormone Binding Globulin (SHBG)
  • ProgesteroneLC/MSFemale panel
  • Prolactin
  • Luteinizing Hormone (LH)
  • Follicle-Stimulating Hormone (FSH)
  • hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

  • Cortisol
  • DHEA-S

Growth hormone / IGF-1

  • Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

  • Thyroid Stimulating Hormone (TSH)
  • Free T4
  • Free T3

Heart Health

9 markers

Cardiovascular health

  • Total Cholesterol
  • HDL Cholesterol
  • LDL Cholesterol
  • LDL:HDL Ratio
  • VLDL Cholesterol
  • Triglycerides
  • Apolipoprotein-B (ApoB)
  • C-Reactive Protein, High Sensitivity (hsCRP)
  • Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

  • Blood Glucose
  • Fasting Insulin
  • HbA1c

Organ Function

26 markers

Liver & pancreas

  • AST
  • ALT
  • Bilirubin, Total
  • γ-Glutamyl Transferase (GGT)

Kidney function

  • BUN
  • Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

  • Glucose
  • Blood Urea Nitrogen (BUN)
  • Creatinine
  • eGFR
  • BUN/Creatinine Ratio
  • Sodium
  • Potassium
  • Chloride
  • Carbon Dioxide, Total
  • Calcium
  • Protein, Total
  • Albumin
  • Globulin, Total
  • Albumin/Globulin (A/G) Ratio
  • Alkaline Phosphatase (ALP)
  • AST
  • ALT

Prostate health

  • Prostate-Specific Antigen (PSA)Male panel
  • Free PSAMale panel
  • % Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

  • Vitamin D, 25-OHD (25-Hydroxy)
  • Magnesium, RBC

Iron status

  • Iron
  • Iron Saturation
  • TIBC
  • UIBC
  • Ferritin

Complete Blood Count (CBC)

  • White Blood Count (WBC)
  • Red Blood Count (RBC)
  • Hemoglobin (Hgb)
  • Hematocrit (HCT)
  • MCV
  • MCH
  • MCHC
  • Red Cell Distribution Width (RDW)
  • Platelets
  • Neutrophils
  • Neutrophils (Absolute)
  • Lymphocytes
  • Lymphocytes (Absolute)
  • Neutrophil/Lymphocyte Ratio
  • Monocytes
  • Monocytes (Absolute)
  • Eosinophils
  • Eosinophils (Absolute)
  • Basophils
  • Basophils (Absolute)
  • Immature Cells
  • Immature Granulocytes
  • Immature Granulocytes (Absolute)
  • NRBC, w/ Reflex for Immature Cells

Clinical evidence

The research behind Kyzatrex® (Oral Testosterone).

CALYPSO Trial: Oral Testosterone Undecanoate (Kyzatrex) for Hypogonadism

Journal of Clinical Endocrinology & Metabolism (2022)

87.8% of men achieved average testosterone in normal range with twice-daily dosing. BP increases averaged 3 to 5 mmHg systolic.

Safety profile

Monitoring & safety information.

Commonly reported side effects

  • Hypertension (requires monitoring)
  • Increased hematocrit
  • Acne
  • GI discomfort without food
  • Headache

Less common but serious risks

  • Blood pressure elevation (FDA hypertension warning)
  • Polycythemia and thrombotic risk
  • Exacerbation of sleep apnea

Generally not appropriate for

  • Prostate or male breast cancer
  • Uncontrolled hypertension
  • Pregnancy
  • Hematocrit >54%

Typical monitoring

  • Blood pressure (critical, baseline, 3 months, then regularly)
  • Serum testosterone (4 to 6h post-dose for peak)
  • Estradiol
  • Hematocrit/CBC
  • PSA
  • Lipid panel

FAQ

Quick answers.

Kyzatrex is an FDA-approved oral testosterone undecanoate using a lipid-based delivery system requiring ingestion with food. Absorbed via intestinal lymphatics, bypassing hepatic first-pass metabolism and avoiding hepatotoxicity of 17-alpha-alkylated oral androgens.
Non-injectable route. Avoids hepatotoxicity via lymphatic absorption. FDA-approved with established safety data. Twice-daily dosing provides stable levels.
Common side effects include: hypertension (requires monitoring), increased hematocrit, acne, gi discomfort without food, headache. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
View all FAQs
See all FAQs

Kyzatrex is an FDA-approved oral testosterone undecanoate using a lipid-based delivery system requiring ingestion with food. Absorbed via intestinal lymphatics, bypassing hepatic first-pass metabolism and avoiding hepatotoxicity of 17-alpha-alkylated oral androgens.

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.