rFSH for Induction of Spermatogenesis in Hypogonadotropic Hypogonadism
Journal of Clinical Endocrinology & Metabolism (1997)
Combined HCG + rFSH induced spermatogenesis in >70% of men with congenital hypogonadotropic hypogonadism.
FSH (Recombinant)
Injectable (SubQ), 1,500IU vialNot available in all statesMarketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.
hormones
FSH (Recombinant)FSH (Recombinant)
Biosynthetic FSH for Sertoli cell stimulation and spermatogenesis. Used in combination with HCG to treat hypogonadotropic hypogonadism and male infertility where FSH deficiency limits sperm production.
Directly addresses FSH-deficient azoospermia
Restores spermatogenesis when combined with HCG
Allows fertility in men with non-functional spermatogenesis
No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible
How it works
Mechanism of action
Binds FSH receptors on testicular Sertoli cells, initiating signaling cascades that regulate spermatogenesis from spermatogonial proliferation through spermatid maturation.
The baseline panel.
Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →
Hormone Profile
12 markers
Sex hormones
- Total TestosteroneLC/MS
- Free TestosteroneEquilibrium Dialysis
- Estradiol, Sensitive / UltrasensitiveLC/MS
- Sex Hormone Binding Globulin (SHBG)
- ProgesteroneLC/MSFemale panel
- Prolactin
- Luteinizing Hormone (LH)
- Follicle-Stimulating Hormone (FSH)
- hCG, Total, QuantitativeFemale panel, pre-menopause
Adrenals & neurosteroids
- Cortisol
- DHEA-S
Growth hormone / IGF-1
- Insulin-Like Growth Factor I (IGF-1)
Thyroid Status
3 markers
Thyroid hormones
- Thyroid Stimulating Hormone (TSH)
- Free T4
- Free T3
Heart Health
9 markers
Cardiovascular health
- Total Cholesterol
- HDL Cholesterol
- LDL Cholesterol
- LDL:HDL Ratio
- VLDL Cholesterol
- Triglycerides
- Apolipoprotein-B (ApoB)
- C-Reactive Protein, High Sensitivity (hsCRP)
- Lipoprotein(a) (Lp(a))
Metabolism
3 markers
Insulin sensitivity
- Blood Glucose
- Fasting Insulin
- HbA1c
Organ Function
26 markers
Liver & pancreas
- AST
- ALT
- Bilirubin, Total
- γ-Glutamyl Transferase (GGT)
Kidney function
- BUN
- Creatinine w/ eGFR
Comprehensive Metabolic Panel (CMP)
- Glucose
- Blood Urea Nitrogen (BUN)
- Creatinine
- eGFR
- BUN/Creatinine Ratio
- Sodium
- Potassium
- Chloride
- Carbon Dioxide, Total
- Calcium
- Protein, Total
- Albumin
- Globulin, Total
- Albumin/Globulin (A/G) Ratio
- Alkaline Phosphatase (ALP)
- AST
- ALT
Prostate health
- Prostate-Specific Antigen (PSA)Male panel
- Free PSAMale panel
- % Free PSAMale panel
Nutrient Status
31 markers
Vitamins & minerals
- Vitamin D, 25-OHD (25-Hydroxy)
- Magnesium, RBC
Iron status
- Iron
- Iron Saturation
- TIBC
- UIBC
- Ferritin
Complete Blood Count (CBC)
- White Blood Count (WBC)
- Red Blood Count (RBC)
- Hemoglobin (Hgb)
- Hematocrit (HCT)
- MCV
- MCH
- MCHC
- Red Cell Distribution Width (RDW)
- Platelets
- Neutrophils
- Neutrophils (Absolute)
- Lymphocytes
- Lymphocytes (Absolute)
- Neutrophil/Lymphocyte Ratio
- Monocytes
- Monocytes (Absolute)
- Eosinophils
- Eosinophils (Absolute)
- Basophils
- Basophils (Absolute)
- Immature Cells
- Immature Granulocytes
- Immature Granulocytes (Absolute)
- NRBC, w/ Reflex for Immature Cells
Clinical evidence
The research behind FSH (Recombinant).
Safety profile
Monitoring & safety information.
Commonly reported side effects
- Injection site reactions
- Headache
- Mild scrotal discomfort
Less common but serious risks
- Allergic reactions to recombinant protein
- Testicular torsion (very rare)
Generally not appropriate for
- Primary testicular failure (Klinefelter)
- Uncontrolled endocrinopathy
- Pituitary/hypothalamic tumor
Typical monitoring
- Semen analysis every 3 months
- LH, FSH, testosterone
- Estradiol
- Inhibin B
FAQ
Quick answers.
Biosynthetic FSH for Sertoli cell stimulation and spermatogenesis. Used in combination with HCG to treat hypogonadotropic hypogonadism and male infertility where FSH deficiency limits sperm production.
Directly addresses FSH-deficient azoospermia. Restores spermatogenesis when combined with HCG. Allows fertility in men with non-functional spermatogenesis.
Common side effects include: injection site reactions, headache, mild scrotal discomfort. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
Biosynthetic FSH for Sertoli cell stimulation and spermatogenesis. Used in combination with HCG to treat hypogonadotropic hypogonadism and male infertility where FSH deficiency limits sperm production.
Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.