MAP.3 Trial: Exemestane for Breast Cancer Prevention
New England Journal of Medicine (2011)
Reduced invasive breast cancer incidence by 65% vs placebo in 4,560 high-risk women.
How it works
Marek's Guided Optimization® Program combines advanced lab testing, a dedicated health coach and medical provider, and a personalized treatment plan, all built around your data.
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The process
1
Start your assessment
Complete your 45-min intake assessment
2
Get your labs drawn
4,000 partnered lab locations nationwide
3
Review with your coach
Screen-by-screen lab review
4
Receive your protocol
Treatment delivered to your door
Why Marek
The only program pairing you with a dedicated health coach and medical provider, built on precision diagnostics, with no subscription required.
Resources
Meet our co-founder
Derek
Co-Founder · MPMD Podcast
"Over time, I found it incredibly difficult to get medical oversight for myself and my family that reflected the latest research, and that was preventative. That's why I started Marek Health."
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What we test
Every client's lab panel is hand-selected from 1,000+ available biomarkers, built around their specific goals.
Panel categories
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Treatments
700+ medical provider-prescribed therapies built from your labs. Browse by category or explore the full formulary.
Exemestane
Oral tablet (25mg)Available in all 50 statesMarketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.
hormones
ExemestaneExemestane
Third-generation steroidal (irreversible/suicide) aromatase inhibitor. Unique androgenic partial agonist property from its steroid backbone may offer bone-protective and libido-supportive advantages over nonsteroidal AIs.
Irreversible, sustained effect, no cross-resistance with nonsteroidal AIs
Androgenic metabolite may reduce bone loss
MAP.3: 65% breast cancer risk reduction
No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible
How it works
Mechanism of action
Irreversibly inactivates aromatase by covalently binding the active site. 17-hydroexemestane metabolite has androgenic properties partially offsetting bone loss. Effect persists until new enzyme is synthesized.
The baseline panel.
Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →
Hormone Profile
12 markers
Sex hormones
- Total TestosteroneLC/MS
- Free TestosteroneEquilibrium Dialysis
- Estradiol, Sensitive / UltrasensitiveLC/MS
- Sex Hormone Binding Globulin (SHBG)
- ProgesteroneLC/MSFemale panel
- Prolactin
- Luteinizing Hormone (LH)
- Follicle-Stimulating Hormone (FSH)
- hCG, Total, QuantitativeFemale panel, pre-menopause
Adrenals & neurosteroids
- Cortisol
- DHEA-S
Growth hormone / IGF-1
- Insulin-Like Growth Factor I (IGF-1)
Thyroid Status
3 markers
Thyroid hormones
- Thyroid Stimulating Hormone (TSH)
- Free T4
- Free T3
Heart Health
9 markers
Cardiovascular health
- Total Cholesterol
- HDL Cholesterol
- LDL Cholesterol
- LDL:HDL Ratio
- VLDL Cholesterol
- Triglycerides
- Apolipoprotein-B (ApoB)
- C-Reactive Protein, High Sensitivity (hsCRP)
- Lipoprotein(a) (Lp(a))
Metabolism
3 markers
Insulin sensitivity
- Blood Glucose
- Fasting Insulin
- HbA1c
Organ Function
26 markers
Liver & pancreas
- AST
- ALT
- Bilirubin, Total
- γ-Glutamyl Transferase (GGT)
Kidney function
- BUN
- Creatinine w/ eGFR
Comprehensive Metabolic Panel (CMP)
- Glucose
- Blood Urea Nitrogen (BUN)
- Creatinine
- eGFR
- BUN/Creatinine Ratio
- Sodium
- Potassium
- Chloride
- Carbon Dioxide, Total
- Calcium
- Protein, Total
- Albumin
- Globulin, Total
- Albumin/Globulin (A/G) Ratio
- Alkaline Phosphatase (ALP)
- AST
- ALT
Prostate health
- Prostate-Specific Antigen (PSA)Male panel
- Free PSAMale panel
- % Free PSAMale panel
Nutrient Status
31 markers
Vitamins & minerals
- Vitamin D, 25-OHD (25-Hydroxy)
- Magnesium, RBC
Iron status
- Iron
- Iron Saturation
- TIBC
- UIBC
- Ferritin
Complete Blood Count (CBC)
- White Blood Count (WBC)
- Red Blood Count (RBC)
- Hemoglobin (Hgb)
- Hematocrit (HCT)
- MCV
- MCH
- MCHC
- Red Cell Distribution Width (RDW)
- Platelets
- Neutrophils
- Neutrophils (Absolute)
- Lymphocytes
- Lymphocytes (Absolute)
- Neutrophil/Lymphocyte Ratio
- Monocytes
- Monocytes (Absolute)
- Eosinophils
- Eosinophils (Absolute)
- Basophils
- Basophils (Absolute)
- Immature Cells
- Immature Granulocytes
- Immature Granulocytes (Absolute)
- NRBC, w/ Reflex for Immature Cells
Clinical evidence
The research behind Exemestane.
Safety profile
Monitoring & safety information.
Commonly reported side effects
- Hot flashes
- Joint pain (potentially less than nonsteroidal AIs)
- Fatigue
- Bone loss (less than other AIs)
Less common but serious risks
- Osteoporosis and fracture risk
- Cardiovascular effects from estrogen suppression
Generally not appropriate for
- Premenopausal women (without ovarian suppression)
- Pregnancy
Typical monitoring
- Serum estradiol
- Testosterone
- DXA
- Liver function
- Lipid panel
FAQ
Quick answers.
Third-generation steroidal (irreversible/suicide) aromatase inhibitor. Unique androgenic partial agonist property from its steroid backbone may offer bone-protective and libido-supportive advantages over nonsteroidal AIs.
Irreversible, sustained effect, no cross-resistance with nonsteroidal AIs. Androgenic metabolite may reduce bone loss. MAP.3: 65% breast cancer risk reduction.
Common side effects include: hot flashes, joint pain (potentially less than nonsteroidal ais), fatigue, bone loss (less than other ais). Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
Third-generation steroidal (irreversible/suicide) aromatase inhibitor. Unique androgenic partial agonist property from its steroid backbone may offer bone-protective and libido-supportive advantages over nonsteroidal AIs.
Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.