How it works

Marek's Guided Optimization® Program combines advanced lab testing, a dedicated health coach and medical provider, and a personalized treatment plan, all built around your data.

Resources

About the program FAQs Pricing Blogs

The process

Start your assessment

Complete your 45-min intake assessment

Get your labs drawn

4,000 partnered lab locations nationwide

Review with your coach

Screen-by-screen lab review

Receive your protocol

Treatment delivered to your door

See the full process

Why Marek

The only program pairing you with a dedicated health coach and medical provider, built on precision diagnostics, with no subscription required.

Resources

Meet our health coaches Our medical providers Clinical advisory board Success stories Brand ambassadors FAQs

Meet our co-founder

Derek

Co-Founder · MPMD Podcast

"Over time, I found it incredibly difficult to get medical oversight for myself and my family that reflected the latest research, and that was preventative. That's why I started Marek Health."

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What we test

Every client's lab panel is hand-selected from 1,000+ available biomarkers, built around their specific goals.

View all biomarkers Order labs directly

Panel categories

Hormone Profile Thyroid Status Heart Health Metabolic Health Organ Function Nutrient Status

Resources

Learn about biomarkers FAQs

Treatments

700+ medical provider-prescribed therapies built from your labs. Browse by category or explore the full formulary.

Browse all treatments See pricing

Browse by category

Hormones Weight Loss Peptides Sexual Health Longevity Thyroid Hair Loss Heart & Metabolic

Supplements

Physician-designed, third-party tested

Self-Service Labs

Order labs directly at Marek Diagnostics

Apparel & Accessories

Shop the Marek Health collection

Evolocumab (Repatha)

Injectable (SubQ), 140mg/mL SureClick auto-injector penAvailable in all 50 states

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

heart

Evolocumab (Repatha)Evolocumab (Repatha)

Fully human monoclonal antibody targeting PCSK9, dramatically increasing LDL receptor recycling. Produces 55 to 60% LDL reduction on top of statin therapy. FOURIER trial demonstrated significant MACE reduction.

55 to 60% LDL reduction on top of statin

FOURIER: 15% MACE reduction, 27% MI reduction

Also reduces Lp(a) by 20 to 30%

Atherosclerotic plaque regression (GLAGOV)

No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible

How it works

Mechanism of action

Binds free circulating PCSK9, preventing it from targeting LDL receptors for lysosomal degradation. Dramatically increases LDL receptor density on hepatocytes, enhancing LDL-C clearance.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

Total TestosteroneLC/MS
Free TestosteroneEquilibrium Dialysis
Estradiol, Sensitive / UltrasensitiveLC/MS
Sex Hormone Binding Globulin (SHBG)
ProgesteroneLC/MSFemale panel
Prolactin
Luteinizing Hormone (LH)
Follicle-Stimulating Hormone (FSH)
hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

Cortisol
DHEA-S

Growth hormone / IGF-1

Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

Thyroid Stimulating Hormone (TSH)
Free T4
Free T3

Heart Health

9 markers

Cardiovascular health

Total Cholesterol
HDL Cholesterol
LDL Cholesterol
LDL:HDL Ratio
VLDL Cholesterol
Triglycerides
Apolipoprotein-B (ApoB)
C-Reactive Protein, High Sensitivity (hsCRP)
Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

Blood Glucose
Fasting Insulin
HbA1c

Organ Function

26 markers

Liver & pancreas

AST
ALT
Bilirubin, Total
γ-Glutamyl Transferase (GGT)

Kidney function

BUN
Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

Glucose
Blood Urea Nitrogen (BUN)
Creatinine
eGFR
BUN/Creatinine Ratio
Sodium
Potassium
Chloride
Carbon Dioxide, Total
Calcium
Protein, Total
Albumin
Globulin, Total
Albumin/Globulin (A/G) Ratio
Alkaline Phosphatase (ALP)
AST
ALT

Prostate health

Prostate-Specific Antigen (PSA)Male panel
Free PSAMale panel
% Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

Vitamin D, 25-OHD (25-Hydroxy)
Magnesium, RBC

Iron status

Iron
Iron Saturation
TIBC
UIBC
Ferritin

Complete Blood Count (CBC)

White Blood Count (WBC)
Red Blood Count (RBC)
Hemoglobin (Hgb)
Hematocrit (HCT)
MCV
MCH
MCHC
Red Cell Distribution Width (RDW)
Platelets
Neutrophils
Neutrophils (Absolute)
Lymphocytes
Lymphocytes (Absolute)
Neutrophil/Lymphocyte Ratio
Monocytes
Monocytes (Absolute)
Eosinophils
Eosinophils (Absolute)
Basophils
Basophils (Absolute)
Immature Cells
Immature Granulocytes
Immature Granulocytes (Absolute)
NRBC, w/ Reflex for Immature Cells

Clinical evidence

The research behind Evolocumab (Repatha).

FOURIER Trial

New England Journal of Medicine (2017)

Reduced LDL by 59% (median 92→30 mg/dL) and MACE by 15%, MI by 27%, stroke by 21% in 27,564 patients.

GLAGOV Trial: Plaque Regression

JAMA (2016)

Significant coronary plaque volume regression by IVUS at LDL ~37 mg/dL.

Safety profile

Monitoring & safety information.

Commonly reported side effects

Injection site reactions
Nasopharyngitis
Back pain
Influenza-like symptoms

Less common but serious risks

No serious class-specific risks established
Very low LDL levels appear safe (EBBINGHAUS confirmed no cognitive effects)

Generally not appropriate for

Prior serious hypersensitivity to evolocumab

Typical monitoring

Lipid panel (LDL-C, ApoB, Lp(a))
Liver function (baseline)
Cognitive assessment if symptomatic

FAQ

Quick answers.

55 to 60% LDL reduction on top of statin. FOURIER: 15% MACE reduction, 27% MI reduction. Also reduces Lp(a) by 20 to 30%. Atherosclerotic plaque regression (GLAGOV).

Common side effects include: injection site reactions, nasopharyngitis, back pain, influenza-like symptoms. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.

View all FAQs

See all FAQs

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.