Raise testosterone without sacrificing fertility.Enclomiphene

Enclomiphene stimulates your body's own testosterone production through the HPG axis, raising T levels while preserving fertility. At Marek, every prescription is preceded by complete labs and reviewed by a partnered licensed medical provider, so eligibility, dose, and monitoring are determined by your data, not a template.

HSA/FSA eligible · No commitmentHSA/FSA eligible · No commitment

Hormones · SERM

Enclomiphene

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

Why Enclomiphene

What makes it different.

Fertility-preserving

Endogenous T production

Daily oral dosing

LH / FSH maintained

What to expect

Your Enclomiphene timeline.

Weeks 1 to 4

HPG axis activation

If your provider determines you're eligible, treatment typically begins at a standard daily dose. Enclomiphene blocks estrogen feedback at the hypothalamus, increasing LH and FSH release. Endogenous testosterone production begins ramping up.

Months 1 to 2

Testosterone rise

Serum testosterone levels climb. Many clients report improved energy, mood, and focus. First follow-up labs confirm hormonal response and guide any dose adjustment.

Months 2 to 4

Optimization

Testosterone stabilizes. Sperm parameters maintained or improved. Your coach monitors estradiol and SHBG to support a balanced protocol.

Month 4+

Sustained protocol

Ongoing monitoring every 3 to 6 months. Some clients transition to TRT after achieving fertility goals; others maintain enclomiphene long-term, at the provider's discretion.

How it works

From sign-up to treatment.From sign-up to your first dose.

Take the assessment

45-min intake with your dedicated health coach. A free health-score quiz is available before the paid intake.

Get your labs drawn

Complete lab panel ordered by your provider, drawn at any of 4,000 partnered lab locations nationwide. Results typically return within 14 days.

Provider reviews your results

A licensed medical provider reviews your labs and history to evaluate whether Enclomiphene is appropriate for you. Eligibility and any prescription are determined at the provider's discretion.

If eligible, treatment ships to your door

If your provider prescribes Enclomiphene, it ships from a licensed pharmacy. Your coach supports you through follow-up labs and ongoing monitoring.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

Total TestosteroneLC/MS
Free TestosteroneEquilibrium Dialysis
Estradiol, Sensitive / UltrasensitiveLC/MS
Sex Hormone Binding Globulin (SHBG)
ProgesteroneLC/MSFemale panel
Prolactin
Luteinizing Hormone (LH)
Follicle-Stimulating Hormone (FSH)
hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

Cortisol
DHEA-S

Growth hormone / IGF-1

Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

Thyroid Stimulating Hormone (TSH)
Free T4
Free T3

Heart Health

9 markers

Cardiovascular health

Total Cholesterol
HDL Cholesterol
LDL Cholesterol
LDL:HDL Ratio
VLDL Cholesterol
Triglycerides
Apolipoprotein-B (ApoB)
C-Reactive Protein, High Sensitivity (hsCRP)
Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

Blood Glucose
Fasting Insulin
HbA1c

Organ Function

26 markers

Liver & pancreas

AST
ALT
Bilirubin, Total
γ-Glutamyl Transferase (GGT)

Kidney function

BUN
Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

Glucose
Blood Urea Nitrogen (BUN)
Creatinine
eGFR
BUN/Creatinine Ratio
Sodium
Potassium
Chloride
Carbon Dioxide, Total
Calcium
Protein, Total
Albumin
Globulin, Total
Albumin/Globulin (A/G) Ratio
Alkaline Phosphatase (ALP)
AST
ALT

Prostate health

Prostate-Specific Antigen (PSA)Male panel
Free PSAMale panel
% Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

Vitamin D, 25-OHD (25-Hydroxy)
Magnesium, RBC

Iron status

Iron
Iron Saturation
TIBC
UIBC
Ferritin

Complete Blood Count (CBC)

White Blood Count (WBC)
Red Blood Count (RBC)
Hemoglobin (Hgb)
Hematocrit (HCT)
MCV
MCH
MCHC
Red Cell Distribution Width (RDW)
Platelets
Neutrophils
Neutrophils (Absolute)
Lymphocytes
Lymphocytes (Absolute)
Neutrophil/Lymphocyte Ratio
Monocytes
Monocytes (Absolute)
Eosinophils
Eosinophils (Absolute)
Basophils
Basophils (Absolute)
Immature Cells
Immature Granulocytes
Immature Granulocytes (Absolute)
NRBC, w/ Reflex for Immature Cells

The science

How Enclomiphene works.

Enclomiphene is the active trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM). It selectively blocks estrogen receptors at the hypothalamus, removing negative feedback and increasing GnRH pulsatility.

Increased GnRH drives higher LH and FSH release from the pituitary, stimulating both endogenous testosterone production and spermatogenesis. Unlike exogenous TRT, the testes continue producing testosterone naturally, maintaining testicular size and function.

Separating out the trans-isomer (enclomiphene) from the cis-isomer (zuclomiphene, the accumulating estrogenic component in traditional Clomid) is associated with a cleaner side-effect profile.

Considered for: secondary hypogonadism in men wanting to preserve fertilityLow testosterone in men of reproductive agePost-TRT recovery protocolsBridge therapy before exogenous TRT

Eligibility, dosing, and outcomes vary. Any prescription is at the discretion of a partnered licensed medical provider based on your labs and medical history.

Clinical evidence

The research behind Enclomiphene.

Enclomiphene citrate raises testosterone and maintains sperm counts

BJU International (2013)

Phase II study in men with secondary hypogonadism showed increased serum testosterone with maintained sperm concentration over 3 months.

Read study →

Comparison of enclomiphene citrate to topical testosterone

Journal of Sexual Medicine (2014)

Randomized trial showed enclomiphene normalized testosterone in hypogonadal men while preserving LH, FSH, and sperm concentration, unlike topical testosterone.

Read study →

Estrogen-receptor blockade for hypogonadism: SERM review

Translational Andrology and Urology (2016)

Review of SERM use (clomiphene / enclomiphene) for restoring HPG-axis function. Highlights efficacy and preserved fertility profile compared with exogenous testosterone therapy.

Read study →

Safety profile

Monitoring & safety information.

Commonly reported side effects

Headache (typically transient)
Mood changes
Visual disturbances (rare; report immediately)
Nausea

Less common but serious risks

Visual disturbances (discontinue if persistent)
Thromboembolic events (rare)
Elevated estradiol (manageable with monitoring)

Generally not appropriate for

History of thromboembolic disease
Significant liver disease
Pituitary disease
Hormone-sensitive cancers

Typical monitoring

Total + Free Testosterone
LH and FSH
Estradiol (sensitive assay)
Liver function and lipids

FAQ

Quick answers.

Eligibility, dose, and duration are determined by a partnered licensed medical provider based on your complete labs and medical history. A prescription is not guaranteed, your provider may recommend Enclomiphene, a different therapy, or a non-pharmacologic approach.

Enclomiphene is generally considered for men with secondary hypogonadism who want to preserve fertility, avoid injections, or aren't ready for lifelong TRT. It's also used as a bridge, men planning families may use enclomiphene now and transition to TRT later. Your provider determines the best approach based on your labs.

TRT provides exogenous testosterone and typically achieves higher serum levels. Enclomiphene raises testosterone through your body's own production, typically to mid-range levels. TRT suppresses fertility; enclomiphene preserves it. The right choice depends on your goals, age, and lab results.

No. Traditional Clomid (clomiphene citrate) contains two isomers: enclomiphene (the active one) and zuclomiphene (which accumulates and is associated with estrogenic side effects). Enclomiphene alone is generally better tolerated.

Commonly reported side effects include headache, mood changes, and nausea. Less common but serious risks include visual disturbances and rare thromboembolic events. Your provider reviews your history to evaluate whether Enclomiphene is appropriate, and your coach helps monitor symptoms throughout.

Pricing starts with a $299 intake assessment with your dedicated health coach. Lab pricing starts at $450. If your provider determines a prescription is appropriate, medication cost is separate and varies. HSA/FSA eligible.

View all FAQs

See all FAQs

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.