Diclegis (Doxylamine + Pyridoxine)

Oral tablet (10mg/10mg)Available in all 50 states

Marketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.

women's health

Diclegis (Doxylamine + Pyridoxine)Diclegis (Doxylamine + Pyridoxine)

FDA-approved combination of doxylamine (antihistamine) and pyridoxine (vitamin B6) for nausea and vomiting of pregnancy (NVP). The only FDA Category A-rated drug for this indication.

FDA Category A, safest pregnancy anti-emetic

Significantly reduces NVP symptoms

Delayed-release formulation for overnight dosing

No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible

How it works

Mechanism of action

Doxylamine blocks H1 histamine receptors in the vomiting center and vestibular system. Pyridoxine (B6) serves as a cofactor in amino acid metabolism and may reduce nausea through serotonergic modulation.

The baseline panel.

Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →

Hormone Profile

12 markers

Sex hormones

Total TestosteroneLC/MS
Free TestosteroneEquilibrium Dialysis
Estradiol, Sensitive / UltrasensitiveLC/MS
Sex Hormone Binding Globulin (SHBG)
ProgesteroneLC/MSFemale panel
Prolactin
Luteinizing Hormone (LH)
Follicle-Stimulating Hormone (FSH)
hCG, Total, QuantitativeFemale panel, pre-menopause

Adrenals & neurosteroids

Cortisol
DHEA-S

Growth hormone / IGF-1

Insulin-Like Growth Factor I (IGF-1)

Thyroid Status

3 markers

Thyroid hormones

Thyroid Stimulating Hormone (TSH)
Free T4
Free T3

Heart Health

9 markers

Cardiovascular health

Total Cholesterol
HDL Cholesterol
LDL Cholesterol
LDL:HDL Ratio
VLDL Cholesterol
Triglycerides
Apolipoprotein-B (ApoB)
C-Reactive Protein, High Sensitivity (hsCRP)
Lipoprotein(a) (Lp(a))

Metabolism

3 markers

Insulin sensitivity

Blood Glucose
Fasting Insulin
HbA1c

Organ Function

26 markers

Liver & pancreas

AST
ALT
Bilirubin, Total
γ-Glutamyl Transferase (GGT)

Kidney function

BUN
Creatinine w/ eGFR

Comprehensive Metabolic Panel (CMP)

Glucose
Blood Urea Nitrogen (BUN)
Creatinine
eGFR
BUN/Creatinine Ratio
Sodium
Potassium
Chloride
Carbon Dioxide, Total
Calcium
Protein, Total
Albumin
Globulin, Total
Albumin/Globulin (A/G) Ratio
Alkaline Phosphatase (ALP)
AST
ALT

Prostate health

Prostate-Specific Antigen (PSA)Male panel
Free PSAMale panel
% Free PSAMale panel

Nutrient Status

31 markers

Vitamins & minerals

Vitamin D, 25-OHD (25-Hydroxy)
Magnesium, RBC

Iron status

Iron
Iron Saturation
TIBC
UIBC
Ferritin

Complete Blood Count (CBC)

White Blood Count (WBC)
Red Blood Count (RBC)
Hemoglobin (Hgb)
Hematocrit (HCT)
MCV
MCH
MCHC
Red Cell Distribution Width (RDW)
Platelets
Neutrophils
Neutrophils (Absolute)
Lymphocytes
Lymphocytes (Absolute)
Neutrophil/Lymphocyte Ratio
Monocytes
Monocytes (Absolute)
Eosinophils
Eosinophils (Absolute)
Basophils
Basophils (Absolute)
Immature Cells
Immature Granulocytes
Immature Granulocytes (Absolute)
NRBC, w/ Reflex for Immature Cells

Clinical evidence

The research behind Diclegis (Doxylamine + Pyridoxine).

Doxylamine-Pyridoxine for NVP: Pivotal RCT

American Journal of Obstetrics and Gynecology (2013)

Significantly reduced PUQE (Pregnancy-Unique Quantification of Emesis) scores vs placebo with excellent safety profile.

Safety profile

Monitoring & safety information.

Commonly reported side effects

Drowsiness
Dry mouth
Headache

Less common but serious risks

Excessive sedation if combined with other CNS depressants

Generally not appropriate for

Concurrent MAO inhibitor use
Known hypersensitivity

Typical monitoring

Symptom assessment
Hydration status

FAQ

Quick answers.

FDA-approved combination of doxylamine (antihistamine) and pyridoxine (vitamin B6) for nausea and vomiting of pregnancy (NVP). The only FDA Category A-rated drug for this indication.

FDA Category A, safest pregnancy anti-emetic. Significantly reduces NVP symptoms. Delayed-release formulation for overnight dosing.

Common side effects include: drowsiness, dry mouth, headache. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.

View all FAQs

See all FAQs

FDA-approved combination of doxylamine (antihistamine) and pyridoxine (vitamin B6) for nausea and vomiting of pregnancy (NVP). The only FDA Category A-rated drug for this indication.

Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.