LoDoCo2 Trial
New England Journal of Medicine (2020)
0.5mg daily reduced MACE by 31% (HR 0.69) in 5,522 stable CAD patients on background statin/antiplatelet.
How it works
Marek's Guided Optimization® Program combines advanced lab testing, a dedicated health coach and medical provider, and a personalized treatment plan, all built around your data.
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The process
1
Start your assessment
Complete your 45-min intake assessment
2
Get your labs drawn
4,000 partnered lab locations nationwide
3
Review with your coach
Screen-by-screen lab review
4
Receive your protocol
Treatment delivered to your door
Why Marek
The only program pairing you with a dedicated health coach and medical provider, built on precision diagnostics, with no subscription required.
Resources
Meet our co-founder
Derek
Co-Founder · MPMD Podcast
"Over time, I found it incredibly difficult to get medical oversight for myself and my family that reflected the latest research, and that was preventative. That's why I started Marek Health."
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What we test
Every client's lab panel is hand-selected from 1,000+ available biomarkers, built around their specific goals.
Panel categories
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Treatments
700+ medical provider-prescribed therapies built from your labs. Browse by category or explore the full formulary.
Colchicine
Oral tablet (0.6mg)Available in all 50 statesMarketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.
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ColchicineColchicine
Ancient alkaloid with potent anti-inflammatory properties. LoDoCo2 and COLCOT trials demonstrated 0.5mg daily significantly reduces MACE in stable CAD and post-ACS, targeting residual inflammatory risk not addressed by lipid lowering.
31% MACE reduction in stable CAD (LoDoCo2)
23% MACE reduction post-ACS (COLCOT)
Targets NLRP3/IL-1beta, additive to statins
Low cost (generic)
No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible
How it works
Mechanism of action
Inhibits tubulin polymerization, disrupting NLRP3 inflammasome activation, neutrophil chemotaxis, and IL-1beta/IL-18 secretion. Potent inhibition of innate inflammatory response underlying plaque destabilization.
The baseline panel.
Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →
Hormone Profile
12 markers
Sex hormones
- Total TestosteroneLC/MS
- Free TestosteroneEquilibrium Dialysis
- Estradiol, Sensitive / UltrasensitiveLC/MS
- Sex Hormone Binding Globulin (SHBG)
- ProgesteroneLC/MSFemale panel
- Prolactin
- Luteinizing Hormone (LH)
- Follicle-Stimulating Hormone (FSH)
- hCG, Total, QuantitativeFemale panel, pre-menopause
Adrenals & neurosteroids
- Cortisol
- DHEA-S
Growth hormone / IGF-1
- Insulin-Like Growth Factor I (IGF-1)
Thyroid Status
3 markers
Thyroid hormones
- Thyroid Stimulating Hormone (TSH)
- Free T4
- Free T3
Heart Health
9 markers
Cardiovascular health
- Total Cholesterol
- HDL Cholesterol
- LDL Cholesterol
- LDL:HDL Ratio
- VLDL Cholesterol
- Triglycerides
- Apolipoprotein-B (ApoB)
- C-Reactive Protein, High Sensitivity (hsCRP)
- Lipoprotein(a) (Lp(a))
Metabolism
3 markers
Insulin sensitivity
- Blood Glucose
- Fasting Insulin
- HbA1c
Organ Function
26 markers
Liver & pancreas
- AST
- ALT
- Bilirubin, Total
- γ-Glutamyl Transferase (GGT)
Kidney function
- BUN
- Creatinine w/ eGFR
Comprehensive Metabolic Panel (CMP)
- Glucose
- Blood Urea Nitrogen (BUN)
- Creatinine
- eGFR
- BUN/Creatinine Ratio
- Sodium
- Potassium
- Chloride
- Carbon Dioxide, Total
- Calcium
- Protein, Total
- Albumin
- Globulin, Total
- Albumin/Globulin (A/G) Ratio
- Alkaline Phosphatase (ALP)
- AST
- ALT
Prostate health
- Prostate-Specific Antigen (PSA)Male panel
- Free PSAMale panel
- % Free PSAMale panel
Nutrient Status
31 markers
Vitamins & minerals
- Vitamin D, 25-OHD (25-Hydroxy)
- Magnesium, RBC
Iron status
- Iron
- Iron Saturation
- TIBC
- UIBC
- Ferritin
Complete Blood Count (CBC)
- White Blood Count (WBC)
- Red Blood Count (RBC)
- Hemoglobin (Hgb)
- Hematocrit (HCT)
- MCV
- MCH
- MCHC
- Red Cell Distribution Width (RDW)
- Platelets
- Neutrophils
- Neutrophils (Absolute)
- Lymphocytes
- Lymphocytes (Absolute)
- Neutrophil/Lymphocyte Ratio
- Monocytes
- Monocytes (Absolute)
- Eosinophils
- Eosinophils (Absolute)
- Basophils
- Basophils (Absolute)
- Immature Cells
- Immature Granulocytes
- Immature Granulocytes (Absolute)
- NRBC, w/ Reflex for Immature Cells
Clinical evidence
The research behind Colchicine.
COLCOT Trial
New England Journal of Medicine (2019)
0.5mg daily reduced MACE by 23% when initiated within 30 days of MI.
Safety profile
Monitoring & safety information.
Commonly reported side effects
- GI intolerance, nausea, diarrhea (10%)
- Myalgia
- Fatigue
Less common but serious risks
- Myopathy/neuromuscular toxicity (with CYP3A4/P-gp inhibitors)
- Colchicine toxicity/overdose, potentially fatal
- Bone marrow suppression (chronic high-dose)
- Azoospermia (temporary)
Generally not appropriate for
- Severe renal impairment (eGFR <15)
- Severe hepatic impairment
- Strong CYP3A4/P-gp inhibitors (cyclosporine, clarithromycin)
Typical monitoring
- CBC
- Renal function
- Liver function
- Drug interaction screening
- GI symptoms
FAQ
Quick answers.
Ancient alkaloid with potent anti-inflammatory properties. LoDoCo2 and COLCOT trials demonstrated 0.5mg daily significantly reduces MACE in stable CAD and post-ACS, targeting residual inflammatory risk not addressed by lipid lowering.
31% MACE reduction in stable CAD (LoDoCo2). 23% MACE reduction post-ACS (COLCOT). Targets NLRP3/IL-1beta, additive to statins. Low cost (generic). Once-daily dosing.
Common side effects include: gi intolerance, nausea, diarrhea (10%), myalgia, fatigue. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
Ancient alkaloid with potent anti-inflammatory properties. LoDoCo2 and COLCOT trials demonstrated 0.5mg daily significantly reduces MACE in stable CAD and post-ACS, targeting residual inflammatory risk not addressed by lipid lowering.
Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.