Apigenin as CD38 Inhibitor and NAD+ Preservation
Nature Chemical Biology (2020)
Apigenin inhibited CD38 enzymatic activity, preserving NAD+ levels in aged mice and improving metabolic function.
How it works
Marek's Guided Optimization® Program combines advanced lab testing, a dedicated health coach and medical provider, and a personalized treatment plan, all built around your data.
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The process
1
Start your assessment
Complete your 45-min intake assessment
2
Get your labs drawn
4,000 partnered lab locations nationwide
3
Review with your coach
Screen-by-screen lab review
4
Receive your protocol
Treatment delivered to your door
Why Marek
The only program pairing you with a dedicated health coach and medical provider, built on precision diagnostics, with no subscription required.
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Meet our co-founder
Derek
Co-Founder · MPMD Podcast
"Over time, I found it incredibly difficult to get medical oversight for myself and my family that reflected the latest research, and that was preventative. That's why I started Marek Health."
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What we test
Every client's lab panel is hand-selected from 1,000+ available biomarkers, built around their specific goals.
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Treatments
700+ medical provider-prescribed therapies built from your labs. Browse by category or explore the full formulary.
Apigenin
Liposomal capsule (50mg)Available in all 50 statesMarketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.
sleep
ApigeninApigenin
Flavonoid found in chamomile, parsley, and celery with anxiolytic and sleep-promoting properties. Acts as a benzodiazepine-site ligand at GABA-A receptors and CD38 inhibitor (NAD+ preservation). Increasingly used in longevity protocols.
Natural GABA-A modulation without dependence
CD38 inhibition preserves NAD+ levels
Anti-inflammatory
Well tolerated
No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible
How it works
Mechanism of action
Binds the benzodiazepine site of GABA-A receptors as a partial agonist, producing mild anxiolytic and sedative effects without full benzodiazepine-like activity. Also inhibits CD38 enzyme, reducing NAD+ consumption and preserving cellular NAD+ levels.
The baseline panel.
Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →
Hormone Profile
12 markers
Sex hormones
- Total TestosteroneLC/MS
- Free TestosteroneEquilibrium Dialysis
- Estradiol, Sensitive / UltrasensitiveLC/MS
- Sex Hormone Binding Globulin (SHBG)
- ProgesteroneLC/MSFemale panel
- Prolactin
- Luteinizing Hormone (LH)
- Follicle-Stimulating Hormone (FSH)
- hCG, Total, QuantitativeFemale panel, pre-menopause
Adrenals & neurosteroids
- Cortisol
- DHEA-S
Growth hormone / IGF-1
- Insulin-Like Growth Factor I (IGF-1)
Thyroid Status
3 markers
Thyroid hormones
- Thyroid Stimulating Hormone (TSH)
- Free T4
- Free T3
Heart Health
9 markers
Cardiovascular health
- Total Cholesterol
- HDL Cholesterol
- LDL Cholesterol
- LDL:HDL Ratio
- VLDL Cholesterol
- Triglycerides
- Apolipoprotein-B (ApoB)
- C-Reactive Protein, High Sensitivity (hsCRP)
- Lipoprotein(a) (Lp(a))
Metabolism
3 markers
Insulin sensitivity
- Blood Glucose
- Fasting Insulin
- HbA1c
Organ Function
26 markers
Liver & pancreas
- AST
- ALT
- Bilirubin, Total
- γ-Glutamyl Transferase (GGT)
Kidney function
- BUN
- Creatinine w/ eGFR
Comprehensive Metabolic Panel (CMP)
- Glucose
- Blood Urea Nitrogen (BUN)
- Creatinine
- eGFR
- BUN/Creatinine Ratio
- Sodium
- Potassium
- Chloride
- Carbon Dioxide, Total
- Calcium
- Protein, Total
- Albumin
- Globulin, Total
- Albumin/Globulin (A/G) Ratio
- Alkaline Phosphatase (ALP)
- AST
- ALT
Prostate health
- Prostate-Specific Antigen (PSA)Male panel
- Free PSAMale panel
- % Free PSAMale panel
Nutrient Status
31 markers
Vitamins & minerals
- Vitamin D, 25-OHD (25-Hydroxy)
- Magnesium, RBC
Iron status
- Iron
- Iron Saturation
- TIBC
- UIBC
- Ferritin
Complete Blood Count (CBC)
- White Blood Count (WBC)
- Red Blood Count (RBC)
- Hemoglobin (Hgb)
- Hematocrit (HCT)
- MCV
- MCH
- MCHC
- Red Cell Distribution Width (RDW)
- Platelets
- Neutrophils
- Neutrophils (Absolute)
- Lymphocytes
- Lymphocytes (Absolute)
- Neutrophil/Lymphocyte Ratio
- Monocytes
- Monocytes (Absolute)
- Eosinophils
- Eosinophils (Absolute)
- Basophils
- Basophils (Absolute)
- Immature Cells
- Immature Granulocytes
- Immature Granulocytes (Absolute)
- NRBC, w/ Reflex for Immature Cells
Clinical evidence
The research behind Apigenin.
Safety profile
Monitoring & safety information.
Commonly reported side effects
- Sedation (desired)
- Mild GI upset
Less common but serious risks
- None significant at standard doses
Generally not appropriate for
- Concurrent sedatives/anxiolytics (additive)
Typical monitoring
- Sleep quality
- Anxiety assessment
FAQ
Quick answers.
Flavonoid found in chamomile, parsley, and celery with anxiolytic and sleep-promoting properties. Acts as a benzodiazepine-site ligand at GABA-A receptors and CD38 inhibitor (NAD+ preservation). Increasingly used in longevity protocols.
Natural GABA-A modulation without dependence. CD38 inhibition preserves NAD+ levels. Anti-inflammatory. Well tolerated. Dual sleep + longevity benefit.
Common side effects include: sedation (desired), mild gi upset. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
Flavonoid found in chamomile, parsley, and celery with anxiolytic and sleep-promoting properties. Acts as a benzodiazepine-site ligand at GABA-A receptors and CD38 inhibitor (NAD+ preservation). Increasingly used in longevity protocols.
Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.