ATAC Trial: Anastrozole vs Tamoxifen
Lancet (2002)
Improved disease-free survival vs tamoxifen with fewer thromboembolic events and endometrial cancers.
Anastrozole
Oral tablet (1mg)Available in all 50 statesMarketing purposes only. Actual medications, if prescribed, are dispensed by a licensed pharmacy.
hormones
AnastrozoleAnastrozole
Third-generation nonsteroidal reversible aromatase inhibitor, slightly less potent than letrozole (85 to 90% vs 97 to 99% estradiol reduction). Most commonly used AI in male hormone optimization for estradiol management during TRT.
Effective estrogen management in men on TRT
More titratable than letrozole
Once-daily oral dosing
Established safety record
No commitment · HSA/FSA eligibleNo commitment · HSA/FSA eligible
How it works
Mechanism of action
Reversibly inhibits CYP19A1, blocking aromatization of androgens to estrogens. More titratable than letrozole for managing estradiol in men with lower risk of over-suppression.
The baseline panel.
Every Marek client receives this baseline panel before a provider review. Your provider may add additional biomarkers based on your health history, symptoms, and goals, pulling from 1,000+ available markers. See more biomarkers →
Hormone Profile
12 markers
Sex hormones
- Total TestosteroneLC/MS
- Free TestosteroneEquilibrium Dialysis
- Estradiol, Sensitive / UltrasensitiveLC/MS
- Sex Hormone Binding Globulin (SHBG)
- ProgesteroneLC/MSFemale panel
- Prolactin
- Luteinizing Hormone (LH)
- Follicle-Stimulating Hormone (FSH)
- hCG, Total, QuantitativeFemale panel, pre-menopause
Adrenals & neurosteroids
- Cortisol
- DHEA-S
Growth hormone / IGF-1
- Insulin-Like Growth Factor I (IGF-1)
Thyroid Status
3 markers
Thyroid hormones
- Thyroid Stimulating Hormone (TSH)
- Free T4
- Free T3
Heart Health
9 markers
Cardiovascular health
- Total Cholesterol
- HDL Cholesterol
- LDL Cholesterol
- LDL:HDL Ratio
- VLDL Cholesterol
- Triglycerides
- Apolipoprotein-B (ApoB)
- C-Reactive Protein, High Sensitivity (hsCRP)
- Lipoprotein(a) (Lp(a))
Metabolism
3 markers
Insulin sensitivity
- Blood Glucose
- Fasting Insulin
- HbA1c
Organ Function
26 markers
Liver & pancreas
- AST
- ALT
- Bilirubin, Total
- γ-Glutamyl Transferase (GGT)
Kidney function
- BUN
- Creatinine w/ eGFR
Comprehensive Metabolic Panel (CMP)
- Glucose
- Blood Urea Nitrogen (BUN)
- Creatinine
- eGFR
- BUN/Creatinine Ratio
- Sodium
- Potassium
- Chloride
- Carbon Dioxide, Total
- Calcium
- Protein, Total
- Albumin
- Globulin, Total
- Albumin/Globulin (A/G) Ratio
- Alkaline Phosphatase (ALP)
- AST
- ALT
Prostate health
- Prostate-Specific Antigen (PSA)Male panel
- Free PSAMale panel
- % Free PSAMale panel
Nutrient Status
31 markers
Vitamins & minerals
- Vitamin D, 25-OHD (25-Hydroxy)
- Magnesium, RBC
Iron status
- Iron
- Iron Saturation
- TIBC
- UIBC
- Ferritin
Complete Blood Count (CBC)
- White Blood Count (WBC)
- Red Blood Count (RBC)
- Hemoglobin (Hgb)
- Hematocrit (HCT)
- MCV
- MCH
- MCHC
- Red Cell Distribution Width (RDW)
- Platelets
- Neutrophils
- Neutrophils (Absolute)
- Lymphocytes
- Lymphocytes (Absolute)
- Neutrophil/Lymphocyte Ratio
- Monocytes
- Monocytes (Absolute)
- Eosinophils
- Eosinophils (Absolute)
- Basophils
- Basophils (Absolute)
- Immature Cells
- Immature Granulocytes
- Immature Granulocytes (Absolute)
- NRBC, w/ Reflex for Immature Cells
Clinical evidence
The research behind Anastrozole.
Anastrozole for Hypogonadism in Men
Fertility and Sterility (2001)
1mg/day significantly increased LH, FSH, and testosterone (~50%) while reducing estradiol in young healthy men.
Safety profile
Monitoring & safety information.
Commonly reported side effects
- Hot flashes
- Joint pain
- Bone loss
- Fatigue
- Headache
Less common but serious risks
- Osteoporosis and fracture risk
- Over-suppression of estradiol in men
Generally not appropriate for
- Premenopausal women (breast cancer)
- Pregnancy
- Severe hepatic/renal impairment
Typical monitoring
- Serum estradiol (sensitive assay), avoid below 15 to 20 pg/mL in men
- Testosterone
- LH, FSH
- DXA
- Lipid panel
FAQ
Quick answers.
Third-generation nonsteroidal reversible aromatase inhibitor, slightly less potent than letrozole (85 to 90% vs 97 to 99% estradiol reduction). Most commonly used AI in male hormone optimization for estradiol management during TRT.
Effective estrogen management in men on TRT. More titratable than letrozole. Once-daily oral dosing. Established safety record.
Common side effects include: hot flashes, joint pain, bone loss, fatigue, headache. Most side effects are dose-dependent and may resolve with continued use or dose adjustment.
Third-generation nonsteroidal reversible aromatase inhibitor, slightly less potent than letrozole (85 to 90% vs 97 to 99% estradiol reduction). Most commonly used AI in male hormone optimization for estradiol management during TRT.
Treatments are dependent on licensed clinical prescription. Client costs vary based on individual labs and panel in treatments and services.