PT-141
Written by: Our Editorial Team
Last updated: 02/13/2023
If you have been considering trying a sexual performance-enhancing agent, or maybe you already have with little to no luck. Well, PT-141 may be just what you need.
What is PT-141
PT-141, also known as bremelanotide, is a peptide hormone that has been developed to treat sexual dysfunction in both men and women. It was developed from the peptide hormone Melanotan-II. In initial testing, Melanotan-II induced darkening of skin pigment but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine of the ten original male volunteer test subjects. Further animal testing showed it to induce sexual mating behaviors, and subsequently, researchers began testing it in humans.
As a result, PT-141 is now used to treat sexual dysfunction in men (erectile dysfunction or impotence) and women (sexual arousal disorder). One study found that men who were unresponsive to/unhappy with Viagra preferred PT-141. And another study in women found it caused a 50% increase in sexually satisfying experiences.
PT-141 currently has no contraindications, and it’s effective even in some men who don’t typically respond to Viagra or Cialis.
How Does it work?
PT-141 works by activating the melanocortin receptors in the brain, which are responsible for regulating sexual arousal and desire. That is to say, PT-141 targets the brain regions responsible for regulating our sexual desire rather than simply increasing blood flow in the penis as a PDE5 inhibitor (i.e., Cialis, Viagra) would.
In other words, it has more of a mental effect than a physical one.
Even though PT-141 can also act on the MC1R receptor, we don’t see the tanning/darkening of the skin observed with Melanotan 2.
Benefits
PT-141 is FDA-approved for hypoactive sexual desire disorder for women, however men have also found it effective
In women, it causes a 50% increase in sexually satisfying experiences.
PT-141 increases sexual desire (through your brain) rather than arousal (what happens physically, i.e., after taking Viagra).
It can treat both organic and psychological male sexual dysfunction.
Compared to other sexual enhancement drugs, PT-141 kicks in almost instantly, whereas other drugs can take hours.
Testimonials from users have reported
Lower refractory period
Increased erectile strength
Enhanced libido
Increased sexual desire
Enhanced orgasms
Improved stamina
Heightened penile sensitivity
Trials
Recent clinical trials have shown that PT-141 effectively treats female sexual arousal disorder (FSAD) and male erectile disorder (ED).
In one study, more than two-thirds of women reported increased desire and arousal, and more than half reported improved lubrication and orgasm.
Similarly, more than two-thirds of men reported an increase in erectile function, and over half reported an increase in sexual satisfaction.
A 2016 study in women taking PT-141 for 12 weeks found an increase in the number of sexually satisfying events and orgasm score, with no adverse events.
In addition to effectively treating sexual dysfunction, PT-141 is also being studied for its potential to treat other conditions such as depression, anxiety, and PTSD. Preliminary research suggests that PT-141 may help regulate the brain's response to stress and improve mood.
PT-141 has also been studied for its potential to treat obesity. In animal studies, PT-141 has been found to reduce appetite and body weight.
Usage
The libido-boosting effects of PT-141 can last multiple days. Because of the long half-life, it allows spontaneity in the bedroom to remain. We often recommend that men or women administer the medication twice per week. However, it can also be used ‘as needed’; just be aware that it can take up to 2 hours to take effect. The most effective administration method is a subcutaneous injection beneath the skin.
The FDA does not recommend using it more than eight times a month.
Warning: Contact your nearest emergency room if your erection lasts more than 2 hours.
Conclusion
In the U.S, ED (erectile dysfunction) affects nearly 20 million men, and FSD (female sexual dysfunction) affects around 30 million women. PT-141 could be a significant game-changer. Users of PT-141 report experiencing stronger sexual desire, bodily engagement, and performance.
PT-141 is a prescription medication. If you are interested in learning more about PT-141 and its potential benefits, talk to a healthcare provider to see if it is right for you.
Disclaimer: This blog post/article is for informational purposes only and does not constitute medical advice. This is not a substitute for professional medical advice and should not be relied upon. If you are considering a treatment, always consult your primary care physician to discuss the risks and benefits.
Sources:
https://jaycampbell.com/peptides/pt-141-the-sexual-peptide/#ftoc-heading-1
Hadley, Mac E., and Robert T. Dorr. “Melanocortin Peptide Therapeutics: Historical
Milestones, Clinical Studies and Commercialization.” Peptides, Elsevier, 18 Jan. 2006,
https://www.sciencedirect.com/science/article/abs/pii/S0196978105004602